Kanamycin

Kanamycin
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Kanamycin: mechanism of action, pharmacokinetics and medical applications
 
Kanamycin is an aminoglycoside antibiotic used to treat infections caused by Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae. It was first isolated from a culture of Streptomyces kanamyceticus in 1957.
 
The mechanism of action of kanamycin is that it binds to bacterial ribosomes and inhibits protein synthesis. This occurs by binding to the 30S subunit of the ribosome, which prevents the transfer RNA from binding to the ribosome and thereby inhibits protein translation.
 
The pharmacokinetics of kanamycin is characterized by the fact that it is poorly absorbed from the gastrointestinal tract and is therefore usually taken orally or in tablet form. Kanamycin can also be administered intramuscularly or intravenously. It is distributed throughout the tissues of the body, but its concentration in the liver, kidneys and lungs is the highest. Kanamycin is excreted from the body through the kidneys.
 
Kanamycin is used to treat a variety of infections, including urinary tract, intestinal, and skin infections. It may also be used to treat infections in patients with immunocompromised conditions such as HIV infection or autoimmune diseases.
 
However, kanamycin has a number of side effects. It can cause allergic reactions such as hives or anaphylaxis. It is also possible to develop intolerance to the drug. In addition, kanamycin may cause some side effects such as nausea, vomiting, diarrhea, and impaired kidney and hearing function.
 
In general, kanamycin is an effective antibiotic that is widely used in medicine. However, its use should be limited due to possible side effects. Patients receiving kanamycin should be carefully monitored by a physician to prevent the occurrence of undesirable effects.

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